Brand name: Zidolam N
Generic name: Lamivudine, Zidovudine and Nevirapine
Manufacturer: Hetero
Dosage form: Tablet
Strength: 150mg/300mg/200mg
Composition: Lamivudine (150 mg) + Zidovudine (300 mg) + Nevirapine (200 mg)
Indication: HIV
Storage: Store at room temperature
Overview
Zidolam N tablet is a combination of three anti-HIV medicines: Lamivudine, Zidovudine, and Nevirapine. It is used for the treatment of HIV (human immunodeficiency virus) infection. This medication is not a permanent cure for HIV infection. It only prevents the multiplication of HIV (human immunodeficiency virus) infection in human cells. It is important to take this medicine as prescribed by your doctor. Do not take this medicine in the wrong way as it may lead to some serious side effects. Close monitoring of liver and kidney function is required during treatment with this medication.
Pharmacodynamics
Lamivudine (Zidolam N):- A nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) in order to disrupt viral DNA synthesis. It can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites work to inhibit the activity of the HIV reverse transcriptase enzyme and act as a chain terminator of DNA synthesis.
Zidovudine (Zidolam N):- Works to inhibit the activity of HIV-1 reverse transcriptase by competing with its natural nucleotide counterpart thymidine triphosphate for incorporation into newly synthesized viral DNA. It is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). This compound is phosphorylated to active metabolites that compete for incorporation into viral DNA. They work to inhibit the HIV reverse transcriptase enzyme competitively and then act as a chain terminator of DNA synthesis.
Nevirapine (Zidolam N):- This compound is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. It is only prescribed after the immune system has declined and infections have become evident.
Usage
Zidolam N tablet is a combination of three antiretroviral medications. This medication boosts your immune system to fight against infection and prevents the virus from multiplying. Zidolam N tablet increases the CD4 cell (white blood cells that protect against infection) count in your blood. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor. The recommended dose of Zidolam N medicine is decided by a doctor according to your previous medical condition and response to the treatment. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately.
Interactions
Zidolam N tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.
Medicine Interactions
- Ganciclovir
- Clozapine
- Atorvastatin
- Fenofibrate
- Clarithromycin
- Etodolac
Disease Interactions
- Myopathy
- Skin rash
- Renal dysfunction
- Liver impairment
- Pancreatitis
- Bone marrow suppression
Alcohol Interaction
- Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.
Contraindication
- Zidolam N tablet is not recommended for use in patients with severe kidney and liver impairment.
- Do not use this medicine if you are allergic to Lamivudine, Zidovudine, and Nevirapine.
- Zidolam N tablet is not recommended in patients known to be hypersensitive.
Side Effects
This medicine may cause some common side effects. Discuss the risks and benefits of the Zidolam N tablets with the doctor before starting the treatment.
- Headache
- Tiredness
- Loss of weight
- Nausea
- Insomnia
- Diarrhea
- Blood in urine
- Irregular heartbeat
- Abnormal dream
- Fever
- Chills
- Loss of strength
- Fatigue
- Sore throat
- Unusual weakness
- Blurred vision
- Indigestion
- Constipation
- Redness of skin
- Abdominal pain
- Heartburn
- Muscle pain
Note – immediately contact your health care provider if any side effects occur.
Dosage
Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule.
Missed Dose
- It is advisable not to miss a dose. If you miss a scheduled dose of Zidolam N tablets, contact your doctor immediately.
Overdose
- In case of an overdose of Zidolam N tablets, the doctor will provide emergency medical treatment.
Warnings
Before starting treatment with Zidolam N medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.
- Contraception
- Use suitable methods of contraception to prevent pregnancy while taking Zidolam N medicine.
- Children and adolescents
- Zidolam N tablets are not recommended for use in children under the age of 18.
Warnings For Female
- Pregnancy
- Do not use Zidolam N medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.
- Breastfeeding
- This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Zidolam N (Lamivudine, Zidovudine, and Nevirapine).
Precautions
- This medication can cause skin rash in some patients.
- Close monitoring of bone mineral density is required during treatment with this medicine.
- Zidolam N tablet may increase the risk of lactic acidosis.
- This medication may increase the risk of immune reconstitution syndrome.
- Close monitoring of liver function is required during treatment with this medication.
Cautions
- Do not drive or operate heavy machinery.
- Do not crush or break the tablet.
- Not safe for pregnant women.
- Do not breastfeed while receiving this medication.
