Brand Name: Triumeq
Generic Name: Abacavir + Dolutegravir + Lamivudine
Manufacturer: ViiV healthcare
Dosage Form: Tablet
Strength: 600mg/50mg/300mg
Composition: Abacavir (600 mg) + Dolutegravir (50 mg) + Lamivudine (300 mg)
Indication: HIV
Packaging: 30 tablet
Storage: Store at room temperature
Overview
Triumeq tablet is a combination of three anti-HIV medicines: Abacavir, Dolutegravir, and Lamivudine. It is used for the treatment of HIV (human immunodeficiency virus) infection. This medication is not a permanent cure for HIV infection. Triumeq only prevents the multiplication of HIV (human immunodeficiency virus) infection in human cells. It is advised not to change your regular dosing schedule without taking suggestions from your doctor. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately.
Pharmacodynamics
Abacavir (Triumeq):- is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). It is phosphorylated to active metabolites that compete for incorporation into viral DNA. They work to inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis.
Dolutegravir (Triumeq):- is an HIV-1 antiviral agent. It works to inhibit HIV integrase and binds to the active site. It blocks the strand transfer step of retroviral DNA integration in the host cell. During the clinical trials, it was indicated that Dolutegravir has a tight binding and longer dissociative half-life.
Lamivudine (Triumeq):- A nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) to disrupt viral DNA synthesis. Lamivudine can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites inhibit the activity of the HIV reverse transcriptase enzyme and then act as a chain terminator of DNA synthesis.
Usage
Triumeq (Abacavir + Dolutegravir + Lamivudine) tablet is a combination of three antiretroviral medications. It is used for the treatment of HIV (human immunodeficiency virus) infection. boosts your immune system to fight against infection and helps to reduce the amount of HIV in your body and improves the quality of life. It is important to take Triumeq tablet as prescribed by your doctor. Do not take this medicine in the wrong way as it may lead to some serious side effects. The recommended dose of Triumeq medication is decided by a doctor according to your previous medical condition and response to the treatment.
Interactions
Triumeq tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.
Medicine Interactions
- Apalutamide
- Carbamazepine
- Emtricitabine
- Kaolin
- Leflunomide
- Primidone
Disease Interactions
- Pancreatitis
- Hepatoxicity
- Renal dysfunction
Alcohol Interaction
- Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.
Contraindication
- Do not use this medicine if you are allergic to Abacavir, Dolutegravir, and Lamivudine
- Triumeq tablet is not recommended in patients known to be hypersensitive.
Side Effects
This medicine may cause some side effects. Discuss the risks and benefits of the Triumeq tablets with the doctor before starting the treatment.
- Dizziness
- Unusual sweating
- Skin rash
- Itching
- Indigestion
- Constipation
- Redness of skin
- Headache
- Taste change
- Blurred vision
- Confusion
- Weight loss
- Sweating
- Mood changes
- Nausea
- Fever
- Chills
- Nightmare
- Stomach ache
- Diarrhea
- Blood in urine
- Irregular heartbeat
- Abnormal dream
- Confusion
- Muscle pain
Note – immediately contact your health care provider if any side effects occur.
Dosage
Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule.
Missed Dose
- It is advisable not to miss a dose. If you miss a scheduled dose of Triumeq tablets, contact your doctor immediately.
Overdose
- In case of an overdose of Triumeq tablets, the doctor will provide emergency medical treatment.
Warnings
Before starting treatment with Triumeq medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.
- Contraception
- Use suitable methods of contraception to prevent pregnancy while taking Triumeq medicine.
- Children and adolescents
- Triumeq tablets are not recommended for use in children under the age of 18.
Warnings For Female
- Pregnancy
- Do not use Triumeq medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.
- Breastfeeding
- This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with
Precautions
- Close monitoring of kidney and liver function is required during treatment with this medicine.
- This medication may increase the risk of immune reconstitution syndrome.
- Inform your doctor if you experience any side effects like- nausea, insomnia, fever, sore throat, headache, abnormal dream, anxiety, etc.
- Triumeq tablet increases the risk of lactic acidosis.
Cautions
- Do not drive or operate heavy machinery.
- Do not crush or break the tablet.
- Not safe for pregnant women.
- Do not breastfeed while receiving this medication.
