Brand Name: Ricovir-L
Generic Name: Lamivudine and Tenofovir disoproxil fumarate
Manufacturer: Mylan
Dosage Form: Tablet
Strength: 300mg/300mg
Composition: Lamivudine (300mg) and Tenofovir disoproxil fumarate (300mg)
Packaging: 30 tablets (30 / strip)
Indication: HIV
Storage: Store at room temperature.
Overview
Ricovir-L (Lamivudine and Tenofovir disoproxil fumarate) tablet is a combination of two antiretroviral medicines. It belongs to a class of medication known as nucleoside reverse transcriptase inhibitors (NRTIs). This medication is used in the treatment of HIV (human immunodeficiency virus) infection. This medication helps to reduce the amount of HIV in your body and boost your immune system to fight against infection. It is important to take Ricovir-L tablets as prescribed by your doctor. It is advised not to change your regular dosing schedule without taking suggestions from your doctor. The recommended dose of Efamat medicine is decided by a doctor according to your previous medical condition and response to the treatment.
Pharmacodynamics
Lamivudine (Ricovir L):- It is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) to disrupt viral DNA synthesis. Lamivudine can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites inhibit the activity of the HIV reverse transcriptase enzyme and then act as a chain terminator of DNA synthesis.
Tenofovir disoproxil fumarate (Ricovir L): It is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. This compound requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate. Tenofovir diphosphate works to inhibit the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5′-triphosphate and, after incorporation into DNA, by DNA chain termination. It is known to be a weak inhibitor of mammalian DNA polymerases alpha, beta, and mitochondrial DNA polymerase gamma.
Usage
Ricovir-L tablet is a combination of two anti-HIV medicines: Lamivudine and Tenofovir disoproxil fumarate. This medication is not a permanent cure for HIV infection. It prevents the virus from multiplying and also increases the CD4 cell (white blood cells that protect against infection) count in your blood. Close monitoring of liver function and kidney function is required during treatment with this medication. Do not take Ricovir L tablet in the wrong way as it may lead to some severe side effects. If you experience any symptoms while receiving this medicine, inform your doctor immediately.
Interactions
Ricovir-L tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.
Medicine Interactions
- Adefovir
- Foscarnet
- Oxaprozin
- Cisplatin
- Tobramycin
- Primidone
- Meloxicam
- Vancomycin
Disease Interactions
- Hepatotoxicity
- Hepatitis B
- Pancreatitis
- Renal impairment
Alcohol Interaction
- Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.
Contraindications
- Do not take this medicine if you are allergic to Lamivudine and Tenofovir disoproxil fumarate.
- Ricovir-L (Lamivudine and Tenofovir disoproxil fumarate) medicine is not recommended in patients known to be hypersensitive.
- This medication is not recommended in patients with severe kidney disease.
Substitutes
- Emfovir
- Tavin-L
- Tenolam L
- Virofovir
- Forstavir L
Side Effects
This medicine may cause some side effects. Discuss the risks and benefits of the Ricovir-L tablets with the doctor before starting the treatment.
Common Side Effects
- Dizziness
- Nausea
- Insomnia
- Fever
- Chest pain
- Diarrhea
- Anxiety
- Headache
- Indigestion
- Trouble sleeping
- Loss of strength
- Fatigue
- Sore throat
- Swollen lymph nodes
- Loss of appetite
- Seizures
- Unusual weakness
- Blurred vision
- Loss of weight
- Unusual tiredness
- Poor concentration
- Increased sweating
- Swelling
- Difficult or painful urination
- Confusion
Note – immediately contact your health care provider if any side effects occur.
Dosage
Take this medicine as prescribed by your doctor. Make sure to not skip or stop your regular dosing schedule.
Missed Dose
- It is advisable not to miss a dose. If you miss a scheduled dose of Ricovir-L tablets, contact your doctor immediately.
Overdose
- In case of an overdose of Ricovir-L tablets, the doctor will provide emergency medical treatment.
Warning
Before starting treatment with Ricovir-L medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.
- Contraception
- Use suitable methods of contraception to prevent pregnancy while taking Ricovir-L medicine.
- Children and adolescents
- Ricovir-L tablets are not recommended for use in children under the age of 18.
Warnings For Female
- Pregnancy
- Do not use Ricovir-L medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.
- Breastfeeding
- This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Ricovir-L (Lamivudine and Tenofovir disoproxil fumarate).
Precautions
- Ricovir-L tablets may increase the risk of immune reconstitution syndrome.
- Inform your doctor if you experience any side effects like- nausea, insomnia, fever, sore throat, headache, allergic reaction, anxiety, etc.
- This medication may increase the risk of pancreatitis in some patients.
- Ricovir-L tablets increase the risk of lactic acidosis.
- Close monitoring of body fat distribution and body weight is required during treatment with this medicine.
Cautions
- Do not drive or operate heavy machinery.
- Do not crush or break the tablet.
- Not safe for pregnant women.
- Do not breastfeed while receiving this medication.
