Overview
Paznib is a cancer-fighting medicine. It contains pazopanib as its salt composition. This drug is available only on prescription. It is used in the treatment of individuals diagnosed with renal cell carcinoma (kidney cancer). Paznib is also prescribed to treat metastatic soft tissue sarcoma. It is available as tablets of 200 mg strength for oral administration only.
Pazopanib is specifically suitable for patients with prior chemotherapy. It works by reducing tumor blood flow and increasing cell apoptosis (cancer cell death). This happens also because of the tumor interstitial fluid pressure reduction.
Pharmacodynamics
Pazopanib (PAZNIB) is a second-generation multitargeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptors-1, -2, and -3, platelet-derived growth factor receptors-alpha, beta, and c-kit. These receptor targets are part of the angiogenesis pathway, which helps tumors survive and develop by facilitating the production of blood vessels.
Interactions
Paznib (Pazopanib) tablets can interact with other drugs, diseases, foods, and alcohol. Here are a few known interactions of this drug.
With Drugs
- Adalimumab
- Cabozantinib
- Lemborexant
- Dolasetron
- Azithromycin
- Erythromycin
- Ivabradine
- Hydrocodone
- Nizatidine
With Diseases
- GI perforation
- CV disease
- Bleeding
- Liver dysfunction
- QT prolongation
- Hypertension
- Hypothyroidism
- Lung dysfunction
- Proteinuria
- Thromboembolic disorders
With Alcohol
Consumption of alcohol during Paznib (Pazopanib) therapy may cause unwanted interactions. Avoid such drinks till you’re using this drug.
Contraindications
Paznib (Pazopanib) tablets are contraindicated for use in the following cases:
- A severe infection
- Low thyroid hormone levels
- Low potassium levels
- Low calcium levels
- A heart attack
- Pregnancy
- Pancreatitis
- Breastfeeding
- Acute thromboembolic stroke
Paznib (Pazopanib) tablets may cause side effects during the treatment period. Consult your doctor if they become unmanageable.
- Nervousness
- Vomiting
- Nosebleeds
- Painful urination
- Bleeding gums
- Pale skin
- Nausea
- Paralysis
- Blood in the urine
- Dizziness
- Cough
- Dry skin and hair
- Feeling cold
- Fever
- Hair loss
- Cloudy urine
- Constipation
- Coughing up blood
- Dark urine
- Blurred vision
- Chest pain
- Headache
- Clay-colored stools
- Chills
Administer Paznib (Pazopanib) tablets on an empty stomach at the same time every day. Take this drug as per the prescription by your doctor. Swallow with water. Do not change the dose strength unless recommended.
Missed Dose
If you miss a dose of Paznib (Pazopanib), contact your doctor to know the ways of coping with it. Do not take twice the strength of the medicine the next time.
Overdose
If you overdose on Paznib (Pazopanib) tablets, you may feel symptoms like difficulty in breathing, nausea, and chest pain. Consult your doctor if your condition worsens eventually.
General Warnings
- Tell your medical team about the drugs, supplements, and OTCs you consume regularly.
- Do not change the dose strength of Paznib tablets unless your doctor recommends it.
- Do not drive or use machines that require high concentration after taking Paznib tablets.
- Do not chew or cut Paznib (Pazopanib) tablets during administration.
Warnings For Females
- Pregnancy
- Do not take Paznib (Pazopanib) tablets during pregnancy. This drug may cause harm to the fetus. Consult your doctor.
- Breastfeeding
- Do not take Paznib (Pazopanib) tablets while breastfeeding. This drug may get excreted in breast milk. Contact your doctor regarding discontinuation of nursing.
Precautions
- Contraception
- Use effective contraception during Paznib (Pazopanib) therapy in order to prevent pregnancy.
- Alcohol
- Consumption of alcohol during Paznib (Pazopanib) therapy may cause unwanted interactions. Avoid such drinks till you’re using this drug.
