Brand Name: Imarech
Generic Name: Imatinib mesylate
Manufacturer: Arechar
Dosage Form: Tablet
Strength: 400mg
Composition: Imatinib mesylate
Indication: Blood cancer
Storage: Store at room temperature
Overview
Imarech contains Imatinib mesylate as an active ingredient and this tablet belongs to a class of medication known as tyrosine kinase inhibitors. This medication is used for the treatment of a type of blood cancer known as CML (chronic myeloid leukemia) ALL (Acute lymphocytic leukemia) and gastrointestinal stromal tumor. Imarech tablet inhibits the proliferation and induces apoptosis (planned cell death) in BCR-ABL positive cells (cancer cells). Do not stop the dosage of Imarech tablets without taking permission from your physician.
Pharmacodynamics
Imatinib is an antineoplastic agent and a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, and it works as a specific inhibitor of several tyrosine kinase enzymes. Chronic myelogenous leukemia is associated with the Philadelphia chromosome promoting the generation of BCR-ABL (mutation, which results from the combination of two genes, known as BCR and ABL). BCR-ABL generates a fusion protein that acts as a constitutively active tyrosine kinase and imatinib works to inhibit this constitutive enzymatic activity.
Usage
Imarech (Imatinib mesylate) is used to treat certain types of cancers of blood cells and it works by preventing the multiplication and division of cancer cells. Do not perform activities that require attention and concentration, and get plenty of rest during the course of this medication to avoid side effects like dizziness and drowsiness. Dosage may vary differently to the patients according to their age, weight, and other health concerns. Do not discontinue the dosage of Imarech tablets without consulting with your healthcare professional.
Interactions
Imarech tablets may interact with other drugs and diseases. It is important to know about the interactions to prevent some unusual effects of this medication.
Medicine Interactions
- Apalutamide
- Mitotane
- Baricitinib
- Colchicine
- Warfarin
- Pimozide
- Etanercept
Disease Interactions
- Cardiovascular disease
- Liver impairment
- Fluid retention
- Bone marrow suppression
- Kidney impairment
Alcohol Interaction
- Consuming alcohol during treatment with Imarech (Imatinib mesylate) tablets may lead to some unwanted risks and side effects. It is advisable to consult your physician or medical practitioner before consuming alcohol.
Contraindications
- Imarech tablet is not recommended in patients having a known allergy to Imatinib mesylate or any other active ingredient present in this medication.
- Not recommended for use in patients known to be hypersensitive.
Alternate
Side Effects
Imarech tablets may cause certain side effects. Discuss the benefits and risks with your medical practitioner; your physician will guide you according to your current state.
Allergic Reactions
- Difficulty in breathing
- Pale skin
- Irregular heartbeat
- Unusual bleeding
- Bloody stool
- Swelling around the eyes
- Bloating
- Presence of blood in cough
- Fatigue
Common Side Effects
- Blurred vision
- Indigestion
- Dizziness
- Weight loss
- Diarrhea
- Nausea
- Itching
- Joint pain
- Abdominal pain
- Joint pain
- Headache
- Weight gain
- Insomnia
- Seizures
- Anxiety
- Vomiting
- Muscle pain
- Heartburn
- Constipation
Note – consult your pharmacist or healthcare professional if any possible side effects occur.
Dosage
Take the Imarech tablet exactly as prescribed by your physician. Do not crush, chew or break the tablet. Be sure to avoid skipping a dose.
Missed Dose
If you miss a dose of Imarech tablet consult a medical practitioner. Do not increase or decrease the strength of your dosage.
Overdose
In case of an overdose of the Imarech (Imatinib mesylate), be sure to consult a healthcare professional or a medical helpline for proper monitoring.
Warnings And Precautions
Before starting the course of Imarech (Imatinib mesylate) tablet, make sure to go through the warning and precautions mentioned below:-
- Use effective methods of contraception to prevent pregnancy while taking Imarech tablets.
- Imarech tablets are safe for use in children and adolescents with CML.
For Females
- Do not take Imarech (Imatinib mesylate) tablet if you are pregnant or planning to become pregnant.
- Imarech tablets are not recommended in breastfeeding. Discuss all the risks and benefits with your healthcare professional or medical practitioner.
General Precautions
- Close monitoring of thyroid hormone is required in some patients.
- Extreme caution is required in patients suffering from heart and blood vessel disorder.
- In children, close monitoring of growth parameters is required during treatment with Imarech (Imatinib mesylate).
- Use of an Imarech tablet may weaken your immune system and make you prone to infections.
- Inform your healthcare provider if you experience side effects like dizziness and blurred vision.
Cautions
- Do not operate heavy machinery
- Do not crush or break the tablet
- Do not overdose
- Do not increase or decrease the dose strength.
