Brand name: Dasakast
Generic name: Dasatinib
Strength: 70 mg
Manufacturer: Aprazer
Dosage form: Tablet
Indication: Blood Cancer
Storage: Store at room temperature.
Overview
Dasakast is an anticancer formulation comprising Dasatinib. It belongs to the class of small molecule antineoplastic breakpoint cluster region-abelson (BCR-ABL) inhibitors. This medicine is used in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Dasakast is administered as an oral-use tablet with a glass of water. It should be taken in the same strength as prescribed by your medical practitioner. The medication should never be missed or overdosed on unless recommended by your GP.
Pharmacodynamics
Dasatinib, at nanomolar concentrations, represses the latter kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ. Based on modeling studies, dasatinib is predicted to bind to varied conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines denoting variants of imatinib mesylate sensitive and resistant condition. The compound hindered the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL.
Interactions
Dasakast (Dasatinib) tablets can interact with medicines, diseases, and alcohol. As per the severity of interactions, the following should be taken into consideration.
With Medicines
- Cisapride
- Diclofenac
- BCG vaccine
- Adalimumab
- Alteplase
- Dabigatran
With Diseases
- Hepatic impairment
- Heart and blood vessel disorder
With Alcohol
- Alcohol can show significant interactions with the ingredients of Dasakast (Dasatinib) tablets. Please talk to your medical practitioner regarding the same prior to the therapy.
Contraindications
The following are some of the contraindications of Dasakast (Dasatinib) tablets:
- Anemia, neutropenia, and thrombocytopenia
- Anticoagulant therapy, bleeding, GI bleeding, and intracranial bleeding
- Edema, pericardial effusion, and pleural effusion
- Lactase deficiency
- Tumor lysis syndrome
- Pulmonary hypertension
- Geriatric
- Children, growth inhibition, infants, and neonates
- Pregnancy
- Breast-feeding
Alternate Brands
The following are some of the common adverse effects that are associated with the use of Dasakast tablets.
- Joint pain
- Bleeding gums
- Constipation
- Loss of appetite
- Difficulty in breathing
- Fatigue
- Nausea
- Infection
- Low blood platelets
- Muscle pain
- Bone pain
- Unusual tiredness
- Chills
- Skin rash
- Weight loss
- Tingling in the arms and feet
- Vomiting
- Anxiety
- Diarrhea
- Blurred vision
- Swelling in your feet
- Irregular heartbeat
- Sore throat
- Headache
- Nasal congestion
- Anemia
- Unusual weakness
- Difficulty with swallowing
- Itching
- Coughing up blood
- Body pain
- Dizziness
- Weight gain
- Pregnancy
During pregnancy, Dasakast (Dasatinib) tablets should be administered only if the doctor prescribes them. Be sure to seek the advice of your health practitioner. - Breastfeeding
During breastfeeding, Dasakast (Dasatinib) tablets should be administered only if the doctor prescribes them. Be sure to seek the advice of your health practitioner. - Kidney
In kidney disease, Dasakast (Dasatinib) tablets should be given with caution. - Liver
In kidney disease, Dasakast (Dasatinib) tablets should be given with caution. - Alcohol
Alcohol and Dasakast (Dasatinib) tablets can interact with each other and cause severe reactions. Be sure to seek the advice of your health practitioner. - Driving
Do not drive after taking Dasakast (Dasatinib) tablets if you experience symptoms like dizziness and blurred vision.
