Brand Name: Daclahep
Generic Name: Daclatasvir
Manufacturer: Hetero
Dosage: Tablet
Strength: 60mg
Composition: Daclatasvir
Packaging: 28 tablet (28 strip)
Indication: Hepatitis C
Storage: Store at room temperature
Overview
Daclahep (Daclatasvir) tablet is used along with other medications for the treatment of Chronic
Hepatitis C. This medicine belongs to a class of drugs known as antiviral agents. It works by
blocking the action of a specific protein and preventing its spread in the body. It is advisable not
to change or stop the dose without taking suggestions from your doctor. If you experience any
symptoms while receiving this medicine, inform your doctor immediately. Do not take this
medicine in the wrong way as it may lead to some severe side effects. Avoid the consumption of
alcohol during the time of treatment with this medicine.
Pharmacodynamics
Daclatasvir is a direct-acting antiviral (DAA) agent that targets the nonstructural protein 5A
(NS5A) and causes a decrease in serum HCV RNA levels. It disrupts HCV replication by
specifically inhibiting the critical functions of a nonstructural protein 5A (NS5A) protein in the
replication complex. After the oral administration, the effect of this medicine can be observed in
2 hours.
Usage
Daclahep is an antiviral medication that is used in combination to treat chronic (when the
infection moves into the long-lasting stage) Hepatitis C virus (HCV). This medicine works by
removing the virus from the blood over a period of time. Take this medicine with or without food
orally once a day. This medication may take some time to show effect. Do not miss your regular
dosing schedule. The recommended dose is decided by a doctor according to your previous
medical condition and response to the treatment. Do not chew or break the tablet and swallow
the whole tablet with a glass of water.
Interactions
Interactions may change how your medication works and increase the risk for side effects. Don’t
forget to disclose your previous medical history with the doctor.
Medicine Interactions
● Clarithromycin
● Nevirapine
● Modafinil
● Atorvastatin
● Ketoconazole
● Bosentan
● Delavirdine
Disease Interaction
● In patients coinfected with hepatitis B and hepatitis C virus, the use of this medicine may
cause a reactivation of HBV.
Alcohol Interaction
● Interaction with alcohol is unknown. Please consult your doctor before consuming
alcohol.
Contraindications
● This medicine is not recommended in patients receiving strong CYP3A inducers.
● Do not take this medicine if you are allergic to Daclatasvir.
● This medicine is not recommended in patients known to be hypersensitive.
Side Effects
This medicine may cause some mild or severe side effects. Discuss the risks and benefits of
this medication with the doctor before starting the treatment.
Common side effects
● Fatigue
● Headache
● Nausea
● Anemia
● Insomnia
● Dizziness
● Shortness of breath
● Chest pain
● Unusual tiredness
● Diarrhea
● Rash
● Irregular heartbeat
● Pale skin
● Unusual weakness
● Allergic reaction
● Upset stomach
● Trouble in sleeping
● Memory problems
● Low blood sugar
● Vomiting
● Abdominal cramps
● Unusual hoarseness
● Swelling of the mouth, face, tongue, or throat
● Itching
Note – Immediate medical attention is required if any side effects occur.
Dosage
Take this medicine as prescribed by your doctor. Do not skip or miss your dosing schedule. This
medicine can be taken with or without food.
Missed dose
● It is advisable not to miss a dose. If you miss a scheduled dose of this medicine, contact
your doctor immediately.
Overdose
● In case of an overdose, the doctor will provide emergency medical treatment.
Warnings
Before starting treatment with this medication, please inform your doctor about your previous
medical history. If you experience any symptoms while receiving this medication, do not ignore
those symptoms because it may lead to higher risk.
● Contraception
○ Use effective methods of contraception to prevent pregnancy while taking this
medicine.
● Children and adolescents
○ This medicine is not advisable for use in children and adolescents.
Warnings For Female
● Pregnancy
○ Do not use this medicine if you are pregnant or planning to become pregnant.
Avoid this medication at the time of pregnancy.
● Breastfeeding
○ This medicine is not recommended in breastfeeding unless it is necessary.
Please consult your medical advisor before starting treatment with this
medication.
Precautions
● Regular monitoring of kidney and liver function tests is required while having treatment
with this medicine.
● Do not stop taking this medicine without your doctor’s advice.
● This medicine may increase the risk of decreased heart rate when it is used along with
other medicines.
● Inform your doctor if you experience any side effects like – nausea, anemia, fatigue,
vomiting, insomnia, and irregular heartbeat.
● Do not skip the regular dosing schedule.
● This tablet may interact with many other medicines. Do not forget to discuss your
medical history with the doctor.
Cautions
● Do not drive or operate heavy machinery.
● Not safe for pregnant women.
● Do not breastfeed while receiving this medication.
● Do not crush or break the tablet.
Substitutes
● Dacihep
● Natdac
● Hepcfix
● Daclitof
