Brand Name :- Cyramza
Generic Name :- Ramucirumab
Manufacturer :- Lilly
Dosage Form :- Injection
Strength :- 500mg/50ml
Composition :- Ramucirumab
Packaging :- 1vial
Indication :- Stomach cancer, non-small cell lung cancer, colorectal cancer.
Storage conditions :- Protect from light. Do not shake or freeze the vial.
Overview
Cyramza (ramucirumab) is a medicine used to treat stomach cancer (that got worse during or after a certain another type of chemotherapy), colorectal cancer, and non-small cell lung cancer that has spread to other parts of the body. This medication interferes with the growth of cancer cells in the body. This medication comes in the form of an injection and it is given as an infusion every 2 to 3 weeks by your doctor or nurse. This medicine works by stopping the formation of blood vessels that brings oxygen and nutrients to tumors. This may slow the growth and spread of tumors.
Pharmacodynamics Of Cyramza (Ramucirumab)
Ramucirumab is a VEGFR2 antagonist that specifically binds VEGFR2 and blocks binding of VEGFR ligands, VEGF-A, VEGF-C and VEGF-D. A dose range of 6-12mg administered every two or three weeks. Ramucirumab systematic exposure increased dose proportionally at doses of 8mg and above and steady-state concentrations were achieved at approximately 12 weeks.
Side Effects Of Cyramza (Ramucirumab)
This medicine may cause some unwanted side effects. If they occur it may require medical attention.
Common Side Effects
- Fainting
- Nausea
- Constipation
- Fever
- Chills
- Vomiting
- Dizziness
- Shortness of breath
- Chest pain
- Diarrhea
- Burning
- Itching
- Swelling
- Weakness
- Shivering
- Sweating
- Pain on the palms of your hand
- Muscle cramps
- Low white blood cell count
- Not feeling hungry
- Low sodium in blood
- Nose bleeds
- Back pain
Serious Side Effects
- Increase in blood pressure
- Severe bleeding
- Abdominal pain
- Bloody urine
- Coughing up blood
- Lightheadedness
- Change in vision
- Slow wound healing
- Signs of kidney problems
Note – Always inform your doctor, if you experience any unusual symptoms
Dosage
This medication is given by slow injection into a vein by doctor or nurse. The dosage is based on your medical condition, weight, age, and response to the treatment.
Missed Dose
- In case you missed a dose, immediately contact your doctor.
Overdose
- Emergency medical treatment required, in case of an overdose.
Usage Of Cyramza (Ramucirumab)
This medication is used to treat stomach cancer, non-small cell lung cancer and it is also approved to treat colorectal cancer. It is also approved for use in combination with docetaxel to treat patients with metastatic non-small cell lung cancer. This medication is given by slow injection into a vein by a doctor or nurse. The dosage is based on your medical condition, weight, age, and response to the treatment.
General Warnings And Precautions
- Cyramza increase the risk of hemorrhage.
- This medication increases the risk of gastrointestinal perforations.
- Impaired wound healing can occur in patients who receive drugs that inhibit VEGF and VEGFR pathways.
- Infusion related observed reactions that include – back pains, chest pain, chills etc.
- Before using this medication tell your doctor about your medical history of kidney disease, high blood pressure, liver disease.
Cautionary Labels
- Increases risk of bleeding
- Close monitoring is necessary
- Not safe for pregnant womens
