Brand Name: Azalpho
Generic Name: Azacitidine lyophilized
Manufacturer: Arechar
Strength: 100mg
Dosage: Injection
Composition: Azacitidine lyophilized
Indication: Blood cancer
Storage: Store at room temperature
Overview
Azalpho (Azacitidine lyophilized) injection is used in the treatment of MDS (Myelodysplastic Syndrome). It belongs to a group of medications known as antimetabolites and it is used to treat some kinds of blood cancer. This medication works by blocking the activity of an enzyme and stop the growth of cancer cells. It is important to take Azalpho injection as prescribed by your doctor. This medication is given as an infusion into your vein under the supervision of a healthcare provider. The recommended dose of Azalpho injection is decided by a doctor according to your previous medical condition and response to the treatment.
Pharmacodynamics
Azacitidine lyophilized is believed to exert its antineoplastic effects by causing hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow. The concentration of azacitidine required for maximum inhibition of DNA methylation in vitro does not cause major suppression of DNA synthesis. After the administration, the effect of this medication can be observed immediately.
Usage
Azalpho injection is an anti-cancer medication that interferes with the growth of DNA and RNA of the cancer cells and stops them from multiplying. This medication is used to treat myelodysplastic syndrome (in which bone marrow produces abnormal blood cells). Do not self-administer Azalpho injection. It is advised not to change your dosing schedule without taking suggestions from your doctor. Avoid drinking alcohol while having treatment with this medication. If you experience any signs and symptoms while receiving Azalpho injection, inform your doctor immediately. Drink plenty of water and keep yourself hydrated. Regular monitoring of liver and kidney function is required during treatment with this medication.
Interactions
Azalpho injection can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.
Medicine Interactions
- Deferiprone
- Leflunomide
- Natalizumab
- Clozapine
- Adalimumab
Disease Interactions
- Hepatic tumor
- Renal impairment
- Anemia
- Hepatic impairment
Alcohol Interaction
- Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.
Contraindication
- Do not take this medicine if you are allergic to Azacitidine lyophilized.
- Azalpho injection is not recommended in patients known to be hypersensitive.
Side Effects
This medicine may cause some common side effects. Discuss the risks and benefits of Azalpho injection with the doctor before starting the treatment.
- Bladder pain
- Vomiting
- Fast heartbeat
- Headache
- Unusual weakness
- Bleeding gums
- Cough
- Nausea
- Fever
- Diarrhea
- Constipation
- Decreased potassium level in blood
- Blurred vision
- Unusual tiredness
- Dizziness
- Chest pain
- Sore throat
- Loss of voice
- Nasal congestion
- Pale skin
- Back pain
- Loss of appetite
- Injection site reactions
- Painful urination
- Runny nose
- Difficulty in breathing
- Bruising
- Swollen glands
Note – immediately contact your healthcare provider if any side effects occur
Dosage
Take this injection as prescribed by your doctor. Your healthcare provider will give you Azalpho injection according to your medical condition.
Missed Dose
- It is advisable not to miss a dose. If you miss an appointment for a scheduled dose of Azalpho injection, contact your doctor immediately.
Overdose
- In case of an overdose of Azalpho injection, the doctor will provide emergency medical treatment.
Warning
Before starting treatment with Azalpho medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.
- Contraception
- Use suitable methods of contraception to prevent pregnancy while taking Azalpho injection.
- Children and adolescents
- Azalpho (Azacitidine lyophilized) injection is not recommended for use in children under the age of 18.
Warnings For Female
- Pregnancy
- Do not use Azalpho medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.
- Breastfeeding
- This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Azalpho (Azacitidine lyophilized).
Precautions
- This medication may increase the risk of anemia.
- Regular monitoring of kidney and liver function is required during treatment with this medication.
- Azalpho (Azacitidine lyophilized) injection increases the risk of tumor lysis syndrome.
- Inform your doctor if you experience any side effects like- nausea, fever, sore throat, headache, diarrhea, blurred vision, vomiting, swollen glands, etc.
Cautions
- Do not drive or operate heavy machinery.
- Do not self-administer.
- Not safe for pregnant women.
- Do not breastfeed while receiving this medication.
