Brand Name: Sprycel
Composition: Dasatinib
Alternative Brand: Dasacine
Manufacturer: BMS India
Dosage Form: Tablet
Strength: 20mg, 50mg, 70mg, 80mg, 100mg, and 140mg.
Composition: Dasatinib
Packaging: 60 tablets
Indication: Blood cancer
Storage: Store at room temperature
Overview
Sprycel (Dasatinib) tablet is used for the treatment of blood cancer. It belongs to a class of medications known as a protein-tyrosine kinase inhibitor. This medicine works by blocking the action of the abnormal protein that signals cancer cells to multiply. It is important to take this medicine as prescribed by your doctor. The recommended dose of Sprycel tablet is decided by a doctor according to your previous medical condition and response to the treatment. Close monitoring of blood cell count is required while having treatment with this medicine. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor.
Pharmacodynamics
Dasatinib inhibited the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. Under the conditions of the assays, Dasatinib was able to overcome imatinib resistance resulting from BCR-ABL kinase domain mutations, activation of alternate signaling pathways involving the SRC family kinases (LYN, HCK), and multi-drug resistance gene overexpression. After the oral administration, the effect of this medicine can be observed between 1 to 6 hours.
Usage
Sprycel medicine is also used in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), a type of white blood cell cancer. It helps to prevent the growth of cancer cells. Take this medicine orally with or without food. Do not take this medicine in the wrong way as it may lead to some severe side effects. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately. Do not take a Sprycel tablet if you are pregnant.
Interactions
Sprycel tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.
Medicine Interactions
- Diclofenac
- Cabozantinib
- Infliximab
- Lepirudin
- Adalimumab
- Oxaprozin
Disease Interactions
- Cardiovascular disease
- Fluid retention
- Hepatic Impairment
- Bone marrow suppression
Alcohol Interactions
- Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.
Contraindications
- Do not take this medicine if you are allergic to Dasatinib.
- Sprycel (Dasatinib) medicine is not recommended in patients known to be hypersensitive.
Side Effects
This medicine may cause some common side effects. Discuss the risks and benefits of the Sprycel tablets with the doctor before starting the treatment.
Common Side Effects
- Bleeding gums
- Constipation
- Coughing up blood
- Body pain
- Dizziness
- Weight gain
- Irregular heartbeat
- Sore throat
- Headache
- Nasal congestion
- Anemia
- Fatigue
- Nausea
- Infection
- Low blood platelets
- Muscle pain
- Tingling in the arms and feet
- Vomiting
- Anxiety
- Diarrhea
- Blurred vision
- Skin rash
- Weight loss
- Loss of appetite
- Difficulty in breathing
- Swelling in your feet
- Unusual weakness
- Difficulty with swallowing
- Bone pain
- Unusual tiredness
- Chills
- Itching
- Joint pain
Note – Immediately contact your doctor or medical practitioner if any side effects occur
Dosage
Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule.
Missed Dose
- It is advisable not to miss a dose. If you miss a scheduled dose of Sprycel tablets, contact your doctor immediately.
Overdose
- In case of an overdose of Sprycel tablets, the doctor will provide emergency medical treatment.
Warnings
Before starting treatment with Sprycel medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.
- Contraception
- Use suitable methods of contraception to prevent pregnancy while taking this medicine.
Warnings For Female
Pregnancy
- Do not use Sprycel medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.
Breastfeeding
- This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with this medication.
Precautions
- Close monitoring of blood count is required while having treatment with this medicine.
- This medicine may increase the risk of bleeding.
- Avoid contact with people who have infections.
- This medicine should be used with caution in patients who have prolongation of QT interval.
- Regular monitoring of blood pressure level is required during treatment with this medicine.
- Do not skip your regular dosing schedule.
Cautions
- Do not drive or operate heavy machinery.
- Do not crush or break the tablet.
- Not safe for pregnant women.
- Do not breastfeed while receiving this medication.
