Brand name- Erlonat
Generics- Erlotinib Hydrochloride
Manufacturer- NATCO pharma
Dosage form- Tablet
Route of Administration- oral
Strength- 100, 150mg
Composition- Erlotinib Hydrochloride
Packaging- bottle
Indication- non-small cell lung cancer (NSCLC) and pancreatic cancer.
Storage- Store at room temperature (10-30°C)
Class of drug- Kinase inhibitor
Mechanism Of Action
It belongs to a class of medications called kinase inhibitors. It works by blocking the action of abnormal protein that signals cancer cells to multiply. This in turn helps to slow or inhibit the spread of cancer cells
Side Effects-
Rashes in the majority of patients.
Diarrhea, Loss of appetite, Fatigue, Partial Hair Loss.
Rarely, ingrown hairs, like eyelashes
Pharmacodynamics
It is study of drug effects and what the medicine does to the body
It inhibits the intracellular phosphorylation of tyrosine kinase associated with epidermal growth factor (EGFR). As the specificity of inhibition with respect to other tyrosine kinase receptors has not been fully characterized. EGFR is also expressed on the cell surface of normal cells and cancer cells
Pharmacokinetics
Study of what body does to the medicine.Erlonat is around 60% absorbed after administration into the body and its bio availability is increased by food to almost100%. Its half-life is 36 hours and it is cleared majorly by CYP3A4 enzyme present in the body.
Minimum effect concentration (MEC)
Minimum concentration of medicine in blood required for producing the therapeutic effects. Its predefined therapeutic MEC is (0.8μg/ml)
Minimum toxic concentration (MTC)
Minimum concentration of medicine in blood above which toxic or adverse effects are precipitated. Its MTC is 1.25μg/ml
Bioavailability Rate
After oral administration, the medicine archived approximately 60% bioavailability, with administration with food enhancing bioavailability to upwards of 100%
Shelf Life
Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at time of manufacture.
Its shelf life is 2years
Substitutes
- Tarceva
- Carac
Alternate Brands
- Erlocip by Cipla Ltd.
- Erlotib 150mg Tablet by Intas.
- Zyceva 150mg Tablet by Zydus.
- Erleva 100 mg/150 mg by Glenmark.
- Erlotirel 100 mg/150 mg by Reliance life Sciences.
Precaution
Consult your doctor before taking this medicine, if you:
Are allergic to ERLONAT 150MG, or any of the ingredients of this medicine or having a severe liver disease or severe kidney disease
If one uses contact lenses and/or have a history of eye problems such as severe dry eyes
Side effects
Common Side Effects
- Abdominal pain
- Bone pain
- Breathlessness
- Constipation
- Cough
- Diarrhea
- Fatigue
- Fever
- Infection
- Muscle pain
- Nausea
- Rash
- Stomatitis (Inflammation of the mouth)
- Vomiting
- Weight loss
Serious Side Effects
Fatigue, loss of appetite, partial hair loss, diarrhea, mouth sores, vomiting, rashes, weight loss, dry skin, eye irritation, weight decrease, infection, edema, pyrexia, and constipation, bone pain, dyspnea, stomatitis and myalgia.
Dosage
Missed Dose
If the patient misses a dose of medicine, skip it and continue with the normal schedule. No need to double the dose
Overdose
Get the emergency medical treatment and contact your physician
Usage
Which disease area
non-small cell lung cancer (NSCLC) and pancreatic cancer
Warnings
General Warning And Precautions
The medicine causes skin rash, dryness, or other irritation. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Stop using skin products that cause dryness or irritation, such as acne medications, harsh soaps or skin cleansers, or skin products that have alcohol.
Cautions
It is usually taken on an empty stomach once a day, at least 1 hour before or 2 hours after eating a meal or snack. Take erlonat at around the same time every day.
