Brand name – Iclusig
Generic name – Ponatinib
Salt composition – Ponatinib
Manufacturer – ARIAD
Dosage form – Oral (tablet)
Packaging – Bottle
Indication – Blood cancer
Storage – Stored at room temperature.
Strength – 15 mg, 45 mg
Gender – Unisex
Prescription required – Yes
Description
Iclusig (Ponatinib) tablet is used in the treatment of adults with leukaemia (cancer of
the white blood cells). It is used to treat the different stages of chronic myeloid
leukaemia (CML), namely chronic, accelerated and blast phases. It is also used in the
treatment of acute lymphoblastic leukaemia (ALL) in certain patients who are
‘Philadelphia-chromosome positive’, which means those patients whose genes have
rearranged themselves to form another special type of a chromosome called
‘Philadelphia-chromosome’. This chromosome leads to the development of Leukaemia.
Pharmacodynamics
Ponatinib is a multi-target kinase inhibitor. Its primary cellular target is the Bcr-Abl
tyrosine kinase protein which is active and works to promote the progression of CML.
This protein arises from the fused Bcr and Abl gene which is commonly known as the
Philadelphia chromosome. Ponatinib is especially useful in the treatment of resistant
CML because it works to inhibit the tyrosine kinase activity of Abl and T315I mutant
kinases. The T315I mutation highly confers resistance in cells. It prevents other Bcr-Abl
inhibitors from binding to the Abl kinase. Some other targets that ponatinib inhibits are
members of the VEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and
KIT, RET, TIE2, and FLT3.
Contraindications
This medicine is not indicated to the patients who have a known allergy to any of the
ingredients of this medicine.
Side Effects
● Skin rash
● Chest pain
● Fever
● Nausea
● Joint or/and muscle pain
● Dry skin
● Constipation
● Weakness
● Drowsiness
● Cough
● Shortness of breath
● Fainting
● Chills
● Confusion
● Mood changes
● Blurred vision
● Unusual bleeding
● Back pain
● Yellowing skin
● Irregular heart rate
Dosage
Normal Dose
Take the dose exactly as your healthcare provider tells you. Do not increase or decrease
the dose strength as per your own wish. Do not crush, chew or break the tablet.
Missed Dose
When you miss a dose, make sure to tell your healthcare provider regarding the same to
get proper guidance. Do not try to double the dose strength in order to catch up.
Overdose
Seek emergency medical support.
Usage Of Medicine
Iclusig (Ponatinib) tablet is used in the treatment of:
● chronic myeloid leukaemia, and
● acute lymphoblastic leukaemia.
Warning And Precautions
● Take the dose exactly as your healthcare provider tells you. Do not increase or
decrease the dose strength as per your own wish. Do not crush, chew or break
the tablet.
● Do tell your healthcare provider beforehand about your medical condition and
medical history, along with the list of medicines you already take.
● In patients with kidney disease, administer this medicine with utmost caution.
● In patients with liver disease, administer this medicine with utmost caution.
● During pregnancy/breastfeeding, take it only if your healthcare provider
prescribes it. Make sure to talk about the potential risks and benefits.
