Brand name – Mydekla
Generic name – Daclatasvir
Manufacturer – Mylan Pharmaceuticals Pvt Ltd
Salt composition – Daclatasvir (60mg)
Storage – Store at room temperature (10-30°C)
Dosage form – Oral (tablet)
Strength – 60 mg
Packaging – Bottle of 28 tablets
Gender – Unisex
Prescription required – Yes
Indication – used in the treatment of chronic Hepatitis C Virus (HCV) infection
Description
Mydekla 60mg tablet is an antiviral medicine. This tablet is used with other medications
in the treatment of chronic (long-lasting) Hepatitis C Virus infection in adults.
Daclatasvir is a direct-acting antiviral (DAA) agent, that works against Hepatitis C Virus
(HCV) and is used for the treatment of chronic HCV genotype 1 and 3 infections. The
active ingredient of the Mydekla 60mg tablet is Daclatasvir.
Pharmacodynamics
Daclatasvir is a direct-acting antiviral (DAA) agent. It targets the NS5A and then causes
a fall in serum HCV RNA levels. It works to disrupt HCV replication by specifically
inhibiting the critical functions of an NS5A protein in the replication complex. It is
demonstrated that it causes downregulation of the hyperphosphorylation of NS5A.
When given at three times the maximum recommended dose, it does not prolong the QT
interval. NS5A is a viral nonstructural phosphoprotein. It is part of a functional
replication complex in charge of viral RNA genome amplification on endoplasmic
reticulum membranes. It binds to HCV RNA. To maintain the HCV replication complex is
mediated by the cis-acting function of basally phosphorylated NS5A and the trans-
the acting function of hyperphosphorylated NS5A works to modulate HCV assembly and
infectious particle formation. Daclatasvir disrupts hyperphosphorylated NS5A proteins
and interferes with the function of new HCV replication complexes. Daclatasvir also
blocks both intracellular viral RNA synthesis and virion assembly/secretion in vivo.
Contraindication
Do not administer this medication if you have a known allergy to Daclatasvir or other
ingredients of Mydekla.
Alternate brands
● Daclacure 60 mg tablet
● Natdac 60 tablet
● Hepcfix 60 mg tablet
● Hepcdac 60 mg tablet
● Dalsiclear 60 tablet
Side Effects
● Fatigue
● Headache
● Nausea
● Insomnia (difficulty in sleeping)
● Anemia
● Diarrhea
● Skin rash
● Dizziness
● Drowsiness
● Unusual tiredness
● Vomiting
Dosage
Normal Dose
Take Mydekla 60 mg tablet exactly as your healthcare provider tells you. Do not skip the
dose. Do not crush or chew the tablet. Administer this tablet only if your healthcare
provider prescribes it.
Missed Dose
If you miss a dose, make sure to take it as soon as you remember. Skip the missed
dose in case it is already the time for your next scheduled dose. Do not double the dose
to catch up.
Overdose
Seek immediate medical attention.
Usage Of Medicine
Mydekla (Daclatasvir 60 mg) Tablet is used in the treatment of chronic (long-lasting)
Hepatitis C Virus infection in adults. It controls the growth of the virus in the body.
Warning And Precautions
● Tell your doctor beforehand about your medical condition and history, along with
the medicines you already take.
● Do not take Mydekla 60mg tablet without your doctor’s prescription. Take it
exactly as your healthcare provider tells you.
● Take Mydekla 60mg tablet exactly as your healthcare provider tells you.
● Do not skip the dose.
● Do not break, crush, or chew the tablet.
● Avoid driving and operating heavy machines, in case you feel unwell after taking
Mydekla 60 mg tablet.
● Avoid consuming foods that are rich in salts.
● Avoid the consumption of alcohol.
● In liver disease, Mydekla 60 mg tablet should be administered with caution.
● In kidney disease, Mydekla 60 mg tablet should be administered with caution.
● During pregnancy and breastfeeding, Mydekla 60 mg tablet shouldn’t be taken
without discussing potential benefits and risks with the healthcare provider.
