Brand name- Z-pac
Generics- Paclitaxel
Manufacturer- RPG Life sciences Ltd.
Dosage form- Injection
Route of Administration- Intravenous (IV)
Strength- 260mg
Composition- Paclitaxel
Packaging- vial
Indication- non-small cell lung cancer (NSCLC) , Breast cancer, Ovarian cancer and pancreatic cancer.
Storage- Do not store above 25°C. Keep the vial save protect from light.
After dilution medicine store in a refrigerator (2 to 8°C) for no more than 24 hours
Class of drug- Taxane derivative
Mechanism Of Action
It do its action by interfering with microtubule structures which assist the cancer cells to divide and multiply. This decreases the growth of cancer cells and eventually kills them.
Side Effects-
Side effects of Z-Pac include fever, low blood cell counts, feeling weak or tired, bleeding, trouble breathing, hair loss, numbness or tingling, swelling in your face, hands, or feet, sores or white patches in or around your mouth, joint or muscle pain, nausea, vomiting, diarrhea and mild redness or tenderness where the medicine was injected.
Pharmacodynamics
It is study of drug effects and what the medicine does to the body
Z-Pac has different pharmacodynamic effects in each disorder like breast cancer, ovarian cancer and advanced non-small cell lung carcinoma.
Pharmacokinetics
Study of what body does to the medicine.After oral administration of a single dose, the time of peak concentration, Tmax, was between 1 and 4 hr.
Minimum effect concentration (MEC)
Minimum concentration of medicine in blood required for producing the therapeutic effects. Its predefined therapeutic range is not known.
Minimum toxic concentration (MTC)
Minimum concentration of medicine in blood above which toxic or adverse effects are precipitated. Its MTC range is not known.
Bioavailability Rate
Bioavailability is low (about 30%).
Shelf Life
Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at time of manufacture.
Its shelf life is 12 months.
Usage
Which disease area
non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, and pancreatic cancer
Alternate Brands
Oncotaxel 260mg Injection- Sun Pharmaceutical Industries Ltd
Cytax 260mg Injection- Intas Pharmaceuticals Ltd
Petaxel 260mg Injection- Biochem Pharmaceutical Industries
Tortaxel 260mg Injection- Torrent Pharmaceuticals Ltd
Precaution
It is an injection to be taken under the directions of a medical professional.
Side Effects
Common Side Effects
- Nausea
- Vomiting
- Weakness
- Low blood platelets
- Rash
- Upper respiratory tract infection
- Urinary tract infection
- Bleeding
- Anemia (low number of red blood cells)
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Hair loss
- Decreased blood pressure
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Diarrhea
- Decreased white blood cell count (neutrophils
Serious Side Effects
- Neutropenia
- Difficult or painful urination
- Dizziness when getting up suddenly from a sitting position
- Fever and chills
- Pale skin
- Allergic Skin Reaction
- Mouth ulcers
- Difficulty in breathing
- Chest discomfort
Dosage
Missed Dose
It is advised not to miss any dose of this medicine. If you missed any dose, contact your doctor immediately
Overdose
Get the emergency medical treatment and contact your physician
Warnings
Before taking Z-Pac, tell the doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using
Cautions
It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it.
