Indication
Tenofovir is used in combination with other antiviral medications in patients with acquired immunodeficiency syndrome (AIDS). Tenofovir is also used for the treatment of chronic hepatitis B infection. It is a nucleotide reverse transcriptase inhibitor and works by decreasing the ability of the viruses to replicate.
Note
SIDE EFFECTS :
- Common side effects include nausea, rash, diarrhea, headache, pain, depression, and weakness.
- Severe side effects include high blood lactate and an enlarged liver.
- Long term use of Tenofovir disoproxil is associated with nephrotoxicity and bone loss.
INTERACTIONS :
- Tenofovir interacts with Didnosine and HIV-1 protease inhibitors. Tenofovir increases Didanosine concentrations and can result in adverse effects such as pancreatitis and neuropathy.
- Tenofovir also interacts with HIV-1 protease inhibitors such as Atazanavir, by decreasing Atazanavir concentrations while increasing Tenofovir concentrations.
OVERDOSE :
- Do not use more than prescribed dose.
- If you suspect you may have overdosed, call your healthcare provider.
- Do not take extra dose to make up for the missed dose.
Precaution
- Tenofovir is a prescription drug and should be used under proper medical guidance and advice.
- Caution to be taken if patient suffering from renal impairment, hepatomegaly or at other liver disease.
